Bcl-10 Antibody (SPM520)

Immunohistochemistry-Paraffin: Bcl10 Antibody (SPM520) [NBP1-35331] Human Tonsil

Product Discontinued

Bcl-10 Antibody (SPM520) Summary

• Immunogen: Recombinant Bcl-10 protein.
• Specificity: This product is specific for Bcl-10
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse
• Gene: BCL10
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50
• Application Notes: This product is useful for Immunohistochemistry Paraffin. If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution). Use recommended dilution for the concentrated vials only.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM PBS (pH 7.4) and 1.0% BSA
• Preservative: 0.1% Sodium Azide
• Purity: Protein A purified

Alternate Names for Bcl-10 Antibody (SPM520)

• B-cell CLL/lymphoma 10CIPERCLAPB-cell lymphoma/leukemia 10
• Bcl10
• Bcl-10
• CARD-containing apoptotic signaling protein
• CARD-containing molecule enhancing NF-kappa-B
• CARD-containing proapoptotic protein
• CARD-like apoptotic protein
• CARMEN
• caspase-recruiting domain-containing protein
• cCARMEN
• c-E10
• c-E10bcl-10
• CED-3/ICH-1 prodomain homologous E10-like regulator
• Cellular homolog of vCARMEN
• cellular-E10
• CIPER
• CLAP
• hCLAP
• Mammalian CARD-containing adapter molecule E10
• mE10
• mE10CARD containing molecule enhancing NF-kB

Background

Bcl-10 is a 31kDa protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCL10
• Entrez:
  • 8915(Human)