BACE-2 Antibody [FITC]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: FITC

BACE-2 Antibody [FITC] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Antibody was raised against a 16 amino acid peptide near the amino terminus of human BACE2. The immunogen is located within amino acids 30 - 80 of BACE2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BACE2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-77309. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

0

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Alternate Names for BACE-2 Antibody [FITC]

• AEPLC
• Asp 1
• ASP1
• ASP21
• Aspartic-like protease 56 kDa
• Aspartyl protease 1
• BACE2
• BACE-2
• beta secretase 2
• beta-secretase 2
• beta-site amyloid beta A4 precursor protein-cleaving enzyme 2
• Beta-site amyloid precursor protein cleaving enzyme 2
• Beta-site APP cleaving enzyme 2
• beta-site APP-cleaving enzyme 2
• beta-site APP-cleaving enzyme 2, EC 3.4.2310ALP5656 kDa aspartic-like protease
• CEAP1
• Down region aspartic protease
• Down syndrome region aspartic protease
• DRAPBAE2
• EC 3.4.23
• EC 3.4.23.45
• memapsin-1
• Membrane-associated aspartic protease 1
• theta-secretase
• transmembrane aspartic proteinase Asp1

Background

BACE2 (Memapsin 1) is a membrane-bound aspartic protease that is highly homologous with BACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating the beta-amyloid peptide and presumably causes Alzheimer's disease (AD), BACE2 has not been demonstrated to be directly involved in APP processing, and its physiological functions remain to be determined. In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cytosolic domains/peptides.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BACE2