ARMER Products

Description

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Bioinformatics

Entrez	23204 Human 54208 Mouse
Uniprot	AAH10281 Human NM_015161 Human NP_055976.1 Human Q15041 Human
Product By Gene ID	23204
Alternate Names	ADP-ribosylation factor-like 6 interacting protein 1 ADP-ribosylation factor-like 6 interacting protein AIP1 Aip-1 apoptotic regulator in the membrane of the endoplasmic reticulum ARL-6-interacting protein 1 ARL6IPaip-1 ARMER KIAA0069ADP-ribosylation factor-like protein 6-interacting protein 1

Research Areas for ARMER

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Apoptosis