APLP-2 Antibody (397702) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 397702
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

APLP-2 Antibody (397702) [Alexa Fluor® 700] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human APLP-2
  Leu30-Ser680
  Accession # Q06481
• Specificity: Detects human APLP-2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse APLP-2 or recombinant human APLP-1 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for APLP-2 Antibody (397702) [Alexa Fluor® 700]

• amyloid beta (A4) precursor-like protein 2
• amyloid precursor protein homolog HSD-2
• Amyloid protein homolog
• amyloid-like protein 2
• APLP2
• APLP-2
• APPH
• APPHCDEI box-binding protein
• APPL2
• CDEBP
• WALPLP2
• YWK-II

Background

Amyloid beta precursor-like protein 2 (APLP-2) is a 120-170 kDa member of the APP family of neuronal type I transmembrane proteins. Its extracellular domain consists of an N-terminal Cys-rich domain, an Asp/Glu-rich acidic region, a Kunitz protease inhibitor (KPI) domain, and a GAG attachment site in the membrane proximal domain. APLP-2 forms both homodimers and heterodimers with APP and APLP-1. Proteolytic cleavage of APLP-2 generates peptides similar to the amyloidogenic A beta peptides and a cytoplasmic fragment that functions as a transcriptional coactivator. Alternate splicing of APLP-2 generates isoforms that lack the KPI domain or contain an insertion that prevents GAG attachment. The extracellular domain of human APLP-2 shares 81% and 93% aa sequence identity with mouse and rat APLP-2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.