Annexin A8/ANXA8 Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

Annexin A8/ANXA8 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Annexin A8/ANXA8
  Ala2-Pro327
  Accession # P13928
• Specificity: Detects human Annexin A8/ANXA8 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) ANXA4, rhANXA5, rhANXA6, rhANXA7, rhANXA11, and rhANXA13A is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Annexin A8/ANXA8 Antibody [Alexa Fluor® 750]

• Annexin A8
• Annexin VIII
• Annexin-8
• Anx8
• ANXA8
• ANXA8L2
• FLJ53095
• VAC-beta
• Vascular anticoagulant-beta

Background

Annexin A8 (ANXA8), also known as VAC-beta, is an approximately 37 kDa member of the Annexin family of calcium-dependent phospholipid-binding proteins. Annexin A8 associates with the cytosolic face of endosomal membranes in the presence of elevated calcium, and it plays a role in endosomal vesicle trafficking. Annexin A8 is widely expressed in epithelial cells, particularly in the tongue, skin, cornea, and pubertal mammary ducts. It is upregulated in mammary hyperplasia and adenocarcinoma as well as infiltrating pancreatic adenocarcinoma. Annexin A8 is also upregulated during osteoclast differentiation at sites of bone loss. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. Also, multiple copies of ANXA8-like sequences are reported on human chromosome 10q11. Human Annexin A8 shares 92% amino acid sequence identity with mouse and rat Annexin A8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.