Amphiphysin/AMPH Antibody [DyLight 488]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 488

Amphiphysin/AMPH Antibody [DyLight 488] Summary

• Immunogen: E. coli-derived recombinant human Amphiphysin/AMPH
  Asn204-Gly300
  Accession # P49418
• Specificity: Detects Amphiphysin/AMPH in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: AMPH
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Amphiphysin/AMPH Antibody [DyLight 488]

• AMPH
• AMPH1
• amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)
• amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen)
• amphiphysin I
• Amphiphysin

Background

Amphiphysin, a neuronal protein first identified in chicken synaptic membranes, is the autoantigen of Stiff-Man Syndrome (SMS) associated with breast cancer. Patient autoantibodies have a distinct pattern of reactivity with amphiphysin, and the dominant autoepitope is located in its C-terminal region, which contains an SH3 domain (1). Amphiphysin is expressed in many neurons, certain endocrine cell types, and spermatocytes (2). study suggests a link between amphiphysin I expression in cancer and amphiphysin I autoimmunity. The enhanced expression of amphiphysin I in some forms of cancer supports the hypothesis that amphiphysin family members may play a role in the biology of cancer cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AMPH