Recombinant Human alpha Endosulfine Protein

Images

 
SDS-Page: alpha Adaptin Protein [NBP1-37076] - 15.5 kDa (141aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human alpha Endosulfine Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-121 of Human alpha Endosulfine

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
ENSA
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
15.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris buffer(pH 8.0) containing 10% glycerol, 1mM DTT
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE
Reconstitution Instructions
Reconstitute with 50 ul of distilled water to a final concentration is 1.0 mg/ml.

Alternate Names for Recombinant Human alpha Endosulfine Protein

  • alpha-endosulfine
  • ARPP-19eMGC4319
  • endosulfine alpha
  • MGC78563
  • MGC8394

Background

ENSA, also known as alpha endosulfine, belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. Recombinant ENSA protein was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol ENSA