alpha Endosulfine Products

Description

alpha Endosulfine is encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. alpha Endosulfine is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Bioinformatics

Entrez	2029 Human
Uniprot	AAH00436 Human AAH04461 Human NM_207168 Human NP_996925 Human O43768 Human
Product By Gene ID	2029
Alternate Names	alpha-endosulfine ARPP-19eMGC4319 endosulfine alpha MGC78563 MGC8394

Research Areas for alpha Endosulfine

Find related products by research area and learn more about each of the different research areas below.

Neuroscience