Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications Flow, IHC, IHC-Fr, ICC/IF
Clone
V17.1
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1) [Janelia Fluor® 549] Summary

Immunogen
Bovine intestinal alkaline phosphatase
Localization
Cell Surface
Specificity
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ALPL
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Alternate Names for Alkaline Phosphatase, Tissue Non-Specific Antibody (V17.1) [Janelia Fluor® 549]

  • Alkaline phosphatase liver/bone/kidney isozyme
  • alkaline phosphatase, liver/bone/kidney
  • alkaline phosphatase, tissue-nonspecific isozyme
  • alkaline phosphomonoesterase
  • APTNAP
  • AP-TNAP
  • EC 3.1.3.1
  • FLJ40094
  • FLJ93059
  • glycerophosphatase
  • HOPS
  • liver/bone/kidney-type alkaline phosphatase
  • MGC161443
  • tissue-nonspecific ALP
  • TNAP
  • TNSALPMGC167935

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47996AF350
Alexa Fluor 405 NBP2-47996AF405
Alexa Fluor 488 NBP2-47996AF488
Alexa Fluor 532 NBP2-47996AF532
Alexa Fluor 594 NBP2-47996AF594
Alexa Fluor 647 NBP2-47996AF647
Alexa Fluor 700 NBP2-47996AF700
Alexa Fluor 750 NBP2-47996AF750
Allophycocyanin NBP2-47996APC
Allophycocyanin/Cy7 NBP2-47996APCCY7
Biotin NBP2-47996B
DyLight 350 NBP2-47996UV
DyLight 405 NBP2-47996V
DyLight 488 NBP2-47996G
DyLight 550 NBP2-47996R
DyLight 594 NBP2-47996DL594
DyLight 650 NBP2-47996C
DyLight 680 NBP2-47996FR
DyLight 755 NBP2-47996IR
FITC NBP2-47996F
HRP NBP2-47996H
Janelia Fluor 549 NBP2-47996JF549
Janelia Fluor 646 NBP2-47996JF646
PE NBP2-47996PE
PE/Atto594 NBP2-47996PEATT594
PE/Cy5.5 NBP2-47996PECY55
PE/Cy7 NBP2-47996PECY7
PerCP NBP2-47996PCP

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Bioinformatics

Gene Symbol ALPL
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