Alkaline Phosphatase, Tissue Non-Specific Products

Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]

Bioinformatics

Entrez	249 Human
Uniprot	NP_000469.3 Human
Product By Gene ID	249
Alternate Names	Alkaline phosphatase liver/bone/kidney isozyme alkaline phosphatase, liver/bone/kidney alkaline phosphatase, tissue-nonspecific isozyme alkaline phosphomonoesterase APTNAP AP-TNAP EC 3.1.3.1 FLJ40094 FLJ93059 glycerophosphatase HOPS liver/bone/kidney-type alkaline phosphatase MGC161443 tissue-nonspecific ALP TNAP TNSALPMGC167935

Research Areas for Alkaline Phosphatase, Tissue Non-Specific

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