Aldehyde Oxidase 1/AOX1 Antibody [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 488

Aldehyde Oxidase 1/AOX1 Antibody [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Aldehyde Oxidase 1/AOX1
  Asn302-Ser531
  Accession # Q06278
• Specificity: Detects human Aldehyde Oxidase 1/AOX1 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Aldehyde Oxidase 1/AOX1 Antibody [Alexa Fluor® 488]

• Aldehyde Oxidase 1
• aldehyde oxidase
• AOAOH1
• AOX1
• EC 1.2.3.1

Background

AOX1 (Aldehyde oxidase 1; also AO and initially termed xanthine dehydrogenase/oxidase) is a 145‑150 kDa member of the large molybdo‑flavo family of enzymes. It is a homodimer widely expressed in cells such as hepatocytes, bronchial and intestinal epithelium and adrenal cortex. It is suggested to oxidize cyclic aldehydes to carboxylic acids and likely converts retinal to retinoic acid, gentistate aldehyde to gentisate and methylmalonate semialdehyde into methylmalonate. Human AOX1 is 1338 amino acids (aa) in length. It contains a 25 kDa N‑terminal region that possesses two Fe/S redox centers (aa 5‑162), a 40 kDa flavin‑containing domain (aa 236‑421), and an 85 kDa C‑terminal region that contains a molybdenum cofactor and substrate‑binding segment (aa 711‑1245). One isoform shows a two aa substitution for aa 354‑356. Over aa 302‑531, human AOX1 shares 82% aa identity with mouse AOX1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.