Aggrecan Antibody (Cat-316)

Product Discontinued

Aggrecan Antibody (Cat-316) Summary

• Immunogen: Feline brain proteoglycans.
• Marker: Chondrocyte Marker
• Specificity: Chondroitin sulfate proteoglycan (CSPG), carbohydrate epitope.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACAN
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:70000
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: Immunohistochemistry: on 4% paraformaldehyde fixed frozen tissue. Immunocytochemistry/Immunofluorescence : 1:2,500 on primary cultures of neurons. ImmunoBlot: 1:200,000 Immunoprecipitation

Reactivity Notes

Rat, Feline

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.1% Sodium Azide
• Purity: Unpurified

Alternate Names for Aggrecan Antibody (Cat-316)

• ACAN
• AGC1
• AGC1SEDK
• aggrecan core protein
• Aggrecan
• Cartilage-specific proteoglycan core protein
• Chondroitin sulfate proteoglycan 1
• Chondroitin sulfate proteoglycan core protein 1
• CSPCP
• CSPG1
• CSPG1aggrecan 1
• CSPGCP
• large aggregating proteoglycan
• MSK16
• MSK16AGCAN
• SEDK

Background

This aggrecan degradation product usually remains within the tissue still complexed to hyaluronan and link protein. Its release from the cartilage usually signals that there has been extensive catabolism of aggrecan, which allows large complexes containing this metabolite to be released from the tissue.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACAN