ADNP Antibody

Immunohistochemistry: ADNP Antibody [NB110-40556] - Sample: FFPE section of human metastatic bone marrow. Antibody: Affinity purified rabbit anti-ADNP used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit .

Immunohistochemistry: ADNP Antibody [NB110-40556] - Sample: FFPE section of human breast adenocarcinoma. Antibody: Affinity purified rabbit anti-ADNP used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit ..

• Reactivity: Hu, Rt, Pm, Pm-Or
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.25 mg/ml

ADNP Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 1050 and the C-terminus (residue 1102) of human Activity-Dependent Neuroprotective Protein using the numbering given in entry NP_056154.1 (GeneID 23394)
• Predicted Species: Orangutan (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADNP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:100-1:500
  • Immunohistochemistry-Paraffin 1:100-1:500
• Control:

  ADNP Overexpression Lysate

Reactivity Notes

Based on 100% sequence identity, this antibody is predicted to react with Gorilla, White-tufted-ear Marmoset, Crab-eating Macaque, Small-eared galago and Northern White-cheeked Gibbon. Rat reactivity reported in scientific literature (PMID: 18571851)

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.25 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ADNP Antibody

• Activity-dependent neuroprotective protein
• activity-dependent neuroprotector homeobox
• activity-dependent neuroprotector
• ADNP homeobox 1
• ADNP
• ADNP1
• ADNP1KIAA0784activity-dependent neuroprotector homeobox protein

Background

The activity-dependent neuroprotective protein (hADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. hADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. hADNP is implicated in maintaining cell survival, perhaps through modulation of p53.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ADNP Antibody (NB110-40556)(1)

Publication using NB110-40556

• Cattano D, Valleggi S, Ma D et al. Xenon induces transcription of ADNP in neonatal rat brain. Neurosci Lett 2008-08-08 [PMID: 18571851] (Rat)

Bioinformatics

• Gene Symbol: ADNP
• Entrez:
  • 23394(Human)
• Uniprot:
  • Q9H2P0(Human)