ADAM9 Antibody (138537) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
138537
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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ADAM9 Antibody (138537) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human ADAM9 Ectodomain
Accession # Q13443
Specificity
Detects human ADAM9 Ectodomain in Western blots. In Western blots, approximately 10% cross-reactivity with the ectodomain of recombinant mouse ADAM9 is observed and no cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15, or 17 is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ADAM9
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunoprecipitation 25 ug/mL
Control
ADAM9 Knockout HeLa Cell Lysate
Publications
Read Publications using
MAB939 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ADAM9 Antibody (138537) [Unconjugated]

  • a disintegrin and metalloproteinase domain 9 (meltrin gamma)
  • ADAM 9
  • ADAM metallopeptidase domain 9 (meltrin gamma)
  • ADAM metallopeptidase domain 9
  • ADAM9
  • Cellular disintegrin-related protein
  • cone rod dystrophy 9
  • CORD9
  • disintegrin and metalloproteinase domain-containing protein 9
  • EC 3.4.24
  • EC 3.4.24.-
  • MCMP
  • MCMPMDC9KIAA0021Mltng
  • MDC9
  • Meltrin gamma
  • Meltrin-gamma
  • Metalloprotease/disintegrin/cysteine-rich protein 9
  • MLTNG
  • Myeloma cell metalloproteinase

Background

ADAM9, also known as MDC9 or meltrin gamma, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain (1). Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Met-turn expected for reprolysins, a disintegrin-like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factor-alpha (TNF-alpha ), the p75 TNF receptor, the beta -amyloid protein precursor, and the c-kit ligand-1, implying that it may participate in shedding of these membrane proteins (2). In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor (3). In addition, it also cleaves oxidized insulin beta -chain and fibronectin (2,4). Besides its catalytic activity, ADAM9 functions as an adhesion molecule through binding of its disintegrin domain to integrins such as alpha v beta 5 and alpha 6 beta 1 (5, 6). The cytoplasmic domain of ADAM9 interacts with Src homology 3
(SH3)‑containing proteins and protein kinase C, and may mediate different signaling pathways (3, 7). ADAM9 is widely expressed in tissues (8).

  1. Moss, et al. (2001) DDT 6:417.
  2. Roghan, et al. (1999) J. Biol. Chem. 274:3531.
  3. Izumi, et al. (1998) EMBO J. 17:7260.
  4. Schwettmann and Tschesche (2001) Prot. Expre. & Purif. 21:65.
  5. Nath, et al. (2000) J. Cell Sci. 113:2319.
  6. Zhou, et al. (2001) Biochem. Biophys. Res. Comm. 280:574.
  7. Howard, et al. (1999) J. Biol. Chem. 274:31693.
  8. Weskamp, et al. (1996) J. Cell. Biol. 132:717.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ADAM9 Antibody (MAB939)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Neutralization, Western Blot.


Filter By Application
Neutralization
(2)
Western Blot
(3)
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Filter By Species
Human
(5)
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Showing Publications 1 - 5 of 5.
Publications using MAB939 Applications Species
M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, F Kataoka, A Hirasawa, N Susumu, D Aoki, Y Okada ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death Cancer Sci., 2018;109(2):471-482. 2018 [PMID: 29247567] (Neutralization, Human) Neutralization Human
CY Lin, CF Cho, ST Bai, JP Liu, TT Kuo, LJ Wang, YS Lin, CC Lin, LC Lai, TP Lu, CY Hsieh, CN Chu, DC Cheng, YP Sher ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT Sci Rep, 2017;7(1):15108. 2017 [PMID: 29118335] (Neutralization, Human) Neutralization Human
Lin C, Chen H, Huang C, Lai L, Lu T, Tseng G, Kuo T, Kuok Q, Hsu J, Sung S, Hung M, Sher Y ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res, 2014;74(18):5229-43. 2014 [PMID: 25060522] (Western Blot, Human) Western Blot Human
Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone P, Petros JA, Marshall FF, Zhau HE, Chung LW Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res., 2006;66(19):9519-26. 2006 [PMID: 17018608] (Western Blot, Human) Western Blot Human
Karadag A, Zhou M, Croucher PI ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin. Blood, 2006;107(8):3271-8. 2006 [PMID: 16373656] (Western Blot, Human) Western Blot Human

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Gene Symbol ADAM9
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