ADAM19 Antibody (164646) [Alexa Fluor® 700]

• Reactivity: Mu
• Applications: WB
• Clone: 164646
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 700

ADAM19 Antibody (164646) [Alexa Fluor® 700] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain
  Asp205-Gly705 (predicted)
  Accession # O35674
• Specificity: Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observ
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ADAM19 Antibody (164646) [Alexa Fluor® 700]

• a disintegrin and metalloproteinase domain 19 (meltrin beta)
• ADAM 19
• ADAM metallopeptidase domain 19
• ADAM19
• disintegrin and metalloproteinase domain-containing protein 19
• EC 3.4.24
• EC 3.4.24.-
• MADDAM
• Meltrin beta
• meltrin-beta
• Metalloprotease and disintegrin dendritic antigen marker
• MLTNBmeltrin beta

Background

ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha 2-Macroglobulin. ADAM19 cleaves at sequences present in myelin basic protein, insulin beta chain, TNF-alpha , TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O35674()