Activin RIIB Antibody (60408) [PE]

• Reactivity: Hu
• Applications: WB
• Clone: 60408
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

Activin RIIB Antibody (60408) [PE] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
  Ser19-Thr134
  Accession # CAA54671
• Specificity: Detects human Activin RIIB in direct ELISAs and Western blots. Shows approximately 5% cross‑reactivity with recombinant human Activin RIIA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACVR2B
• Purity: Protein A or G purified from ascites

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from ascites

Alternate Names for Activin RIIB Antibody (60408) [PE]

• activin A receptor, type IIB
• Activin receptor type IIB
• activin receptor type-2B
• Activin RIIB
• ActivinRIIB
• ACTRIIB
• ActR-IIB
• ACVR2B
• EC 2.7.11
• EC 2.7.11.30
• MGC116908

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACVR2B