ACD Antibody

Western Blot: ACD Antibody [H00065057-B01P] - Analysis of ACD expression in HepG2.

Western Blot: ACD Antibody [H00065057-B01P] - Analysis of ACD expression in transfected 293T cell line by ACD polyclonal antibody. Lane 1: ACD transfected lysate(59.84 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

ACD Antibody Summary

• Immunogen: ACD (AAH16904.1, 1 a.a. - 544 a.a.) full-length human protein. MPGRCQSDAAMRVNGPASRAPAGWTSGSLHTGPRAGRPRAQARGVRGRGLLLRPRPAKELPLPRKGGAWAPAGNPGPLHPLGVAVGMAGSGRLVLRPWIRELILGSETPSSPRAGQLLEVLQDAEAAVAGPSHAPDTSDVGATLLVSDGTHSVRCLVTREALDTSDWEEKEFGFRGTEGRLLLLQDCGVHVQVAEGGAPAEFYLQVDRFSLLPTEQPRLRVPGCNQDLDVQKKLYDCLEEHLSESTSSNAGLSLSQLLDEMREDQEHQGALVCLAESCLTLEGPCTAPPVTHWAASRCKATGEAVYTVPSSMLCISENDQLILSSLGPCQRTQGPELPPPDPALQDLSLTLIASPPSSPSSSGTPALPGHMSSEESGTSISLLPALSLAAPDPGQRSSSQPSPAICSAPATLTPRSPHASRTPSSPLQSCTPSLSPRSHVPSPHQALVTRPQKPSLEFKEFVGLPCKNRPPFPRTGATRGAQEPCSVWEPPKRHRDGSAFQYEYEPPCTSLCARVQAARLPPQLMAWALHFLMDAQPGSEPTPM
• Specificity: ACD - adrenocortical dysplasia homolog (mouse),
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: ACD
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ACD Antibody

• adrenocortical dysplasia homolog (mouse)
• Pip1
• PIP1Tint1
• POT1 and TIN2 organizing protein
• POT1 and TIN2-interacting protein
• Ptop
• PTOPTpp1
• TIN2 interacting protein 1
• TINT1adrenocortical dysplasia protein homolog
• TPP1

Background

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ACD Antibody (H00065057-B01P)(1)

Publication using H00065057-B01P

• Guo Y, Kartawinata M, Li J et al. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood. 2014-10-30 [PMID: 25205116] (WB, Human)

Bioinformatics

• Gene Symbol: ACD
• Entrez:
  • 65057(Mouse)
• Uniprot:
  • AAH16904.1(Human)