A fusion protein construct that contains the N-terminal region of human ACAT1. [UniProt# P35610]
Endoplasmic reticulum, membrane
This product is specific for protein corresponding to ACAT1 - Sterol O-acyltransferase 1 (SOAT1) Uniprot# P35610, Gene ID# 6646.
[Important Note:- ACAT1 is a symbol for both acyl-Coenzyme A: cholesterol acyltransferase 1 (SOAT1/ACAT1) and for acetyl-CoA acetyltransferase 1 (ACAT1/ THIL, Gene ID 38, Uniprot P24752) which often cause confusion].
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This ACAT1 antibody is useful for Immunoprecipitation and Western blot. Immunocytochemistry/Immunofluorescence was reported in scientific literature. In Western blot a band is observed at ~46 kDa representing ACAT1 along with a non-specific band at ~30 kDa.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
46 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SOAT1 (sterol O-acyltransferase 1), also designated ACAT1, is a homotetrameric
enzyme that catalyzes the formation of cholesterol esters from cholesterol
and long-chain fatty acyl coenzyme A. The gene encoding human SOAT1
maps to chromosome 1 and is expressed as a protein that localizes to the
endoplasmic reticulum (ER) in several tissues, including liver, kidney, adrenal
glands and macrophages. SOAT1 is involved in cellular cholesterol homeostasis
as well as in foam cell formation and the subsequent progression of
atherosclerosis. Several SOAT inhibitors have been developed for the treatment
of atherosclerosis. SOAT2 (sterol O-acyltransferase 2), also known as
ACAT2 (acyl coenzyme A), participates in lipoprotein assembly, catalyzing
cholesterol esterification in mammalian cells. SOAT2 is an integral membrane
protein that localizes to the ER of human intestinal cells. SOAT2 deficiency
contributes to severe mental retardation and hypotonus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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