ABCC5 Antibody (M5II-54)

Product Discontinued

ABCC5 Antibody (M5II-54) Summary

• Immunogen: The antibody reacts with the MRP5 antigen.
• Specificity: M5II-54 reacts with an internal epitope of MRP5, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP. M5II-54 was raised against a bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein. M5I-1 does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ABCC5
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: M5II-54 has potential value for detection of MRP5-mediated drug-resistance samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M5II-54 (use 1:20) on acetone fixed frozen sections can be followed

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Tissue culture supernatant
• Preservative: 0.1% Sodium Azide
• Concentration: This product is unpurified. The exact concentration of antibody is not quantifiable.
• Purity: Tissue culture supernatant

Alternate Names for ABCC5 Antibody (M5II-54)

• ABCC5
• ATP-binding cassette sub-family C member 5
• ATP-binding cassette, sub-family C (CFTR/MRP), member 5
• canalicular multispecific organic anion transporter C
• EC 7.6.2.-
• EC 7.6.2.2
• EST277145
• MOAT-C
• MOAT-CABC33
• MRP5
• MRP5MOATC
• multidrug resistance-associated protein 5
• Multi-specific organic anion transporter C
• pABC11
• SMRP
• SMRPDKFZp686C1782

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCC5