ABAT Antibody (OTI6C9) [HRP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: OTI6C9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: HRP

ABAT Antibody (OTI6C9) [HRP] Summary

• Immunogen: Recombinant protein fragment corresponding to amino acids 29-323 of human ABAT (NP_065737) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ABAT
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for ABAT Antibody (OTI6C9) [HRP]

• (S)-3-amino-2-methylpropionate transaminase
• 4-aminobutyrate aminotransferase
• 4-aminobutyrate aminotransferase, mitochondrial
• 4-aminobutyrate transaminase
• ABAT
• EC 2.6.1.19
• EC 2.6.1.22
• FLJ17813
• FLJ30272
• G
• GABA aminotransferase
• GABA transaminase
• GABA transferase
• GABA-AT
• GABAT
• GABA-T
• GABATNPD009
• Gamma-amino-N-butyrate transaminase
• hCG1984265
• L-AIBAT

Background

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABAT