11 beta-HSD1 Antibody (JU18-39)

Western Blot: 11 beta-HSD1 Antibody (JU18-39) [NBP2-75392] - Analysis of HSD11B1 on mouse liver tissue lysate using anti-HSD11B1 antibody at 1/500 dilution.

Immunohistochemistry-Paraffin: 11 beta-HSD1 Antibody (JU18-39) [NBP2-75392] - Analysis of paraffin-embedded mouse liver tissue using anti-HSD11B1 antibody. Counter stained with hematoxylin.

Immunohistochemistry-Paraffin: 11 beta-HSD1 Antibody (JU18-39) [NBP2-75392] - Analysis of paraffin-embedded human liver tissue using anti-HSD11B1 antibody. Counter stained with hematoxylin.

Product Discontinued

11 beta-HSD1 Antibody (JU18-39) Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Synthetic peptide within Human 11 beta-HSD1 aa 1-50 / 292. (SwissProt: P28845 Human; SwissProt: P50172 Mouse; SwissProt: P16232 Rat)
• Localization: Endoplasmic reticulum, Membrane.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: HSD11B1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 32 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: TBS (pH7.4), 0.05% BSA, 40% Glycerol
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for 11 beta-HSD1 Antibody (JU18-39)

• 11 betaHSD1
• 11 beta-HSD1
• 11-beta-hydroxysteroid dehydrogenase 1
• EC 1.1.1
• EC 1.1.1.146
• HDL
• HSD11B1
• HSD11HSD11B
• HSD11LMGC13539
• hydroxysteroid (11-beta) dehydrogenase 1
• member 1
• SDR26C1

Background

HSD11B1 is encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HSD11B1