Antibodies

CiteAb 2017 Antibody Awards: The Lifetime Achievement Award Recipient Karen Padgett

The CiteAb Lifetime Achievement Award recognizes and promotes an individual who has made an outstanding contribution to the research antibody industry over a sustained period of time.

Immunophenotyping: A Process of Identifying Cells and Cell Markers

Flow cytometry is one of the powerful tools for the investigators in immunological research involved in studying various immune cells. One of the main advantages of this technique is that is capable of multi-parameter measurements that can be accomplished on a single-cell basis. As a result of the advances in the flow cytometry researchers can now decrypt the phenotypes of several cell subsets in ways that were not possible using traditional assays, such as Western/immunoblotting, microarrays and enzyme-linked immunosorbent assays.

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SR-BI Antibodies: A Potential for Blocking Hepatitis C Uptake

Scavenger Receptor Class B Membrane 1, also known as SR-BI plays an important role in lipid metabolism. Its main function is to mediate transfer of cholesterol between the cell surface and high density lipoprotein (HDL). HDL acts as an extracellular donor and acceptor of free and esterified Cholesterol. SR-BI also acts as a receptor for other ligands including lipoproteins, apoptotic cells and phospholipids.

TNF Alpha Antibodies: Potential Therapeutic Tools

Tumor necrosis factor alpha, or TNF alpha antibody products are widely used in cytokine and immunology research. TNF alpha is a pleiotropic ligand which plays an essential role in apoptosis, immune system development and the inflammatory response.

Using Ubiquitin Antibodies in Various Disease Research

Ubiquitin is a small, highly conserved protein which plays an important role in protein breakdown, covalently bonding to proteins to mark them for proteolytic degradation in a process called ubiquitination. Ubiquitin also binds to inclusion bodies (accumulations of protein) in pathological conditions such as Parkinson’s and Alzheimer's disease.

The Role of the MMP2 Antibody in Colorectal Cancer Research

The enzymes of the Matrix Metalloproteinase (MMP) family assist in the degradation of the extracellular matrix, under both normal and pathological conditions. MMP antibodies have identified roles in a number of physiological processes, such as embryonic development and tissue remodelling. They also regulate enzyme cascades, expression of various proteins and the migration of both normal and malignant cells.

BDNF Antibodies and Synaptic Research

Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophins. During development it regulates the survival and differentiation of neuronal cell populations in the central and peripheral nervous system, while in adult synapses it is a major regulator of development, plasticity and transmission.

The Latest Research on IBR-type E3 Ubiquitin Ligases

E3 ubiquitin ligases are standards in most antibody catalogs. These proteins are essential to the process of ubiquitination, which is expressed in protein pathways throughout the body and is often linked to disease states. It is widely used as a biomarker, with ubiquitin antibodies being widely used to identify the protein accumulations (inclusion bodies) which occur in conditions such as Alzheimer’s, Parkinson’s and Huntington's disease.

Chinese Cancer Study Reveals Three New Genes for Nasopharyngeal Carcinomas

A large percentage of the products in our antibody catalog are used for cancer research. Some oncogenes are expressed in several types of tumor, while others are quite specific. For example, there are several products on our antibody database which target genes specific to nasopharyngeal carcinomas (NPC), such as UBAP1 and MMP9. Recently, a Chinese cancer study, which used no fewer than 10,000 volunteer subjects, uncovered 3 new susceptibility genes for NPC.

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