The ABCA1 (ATP-binding cassette transporter-A1) gene encodes a transmembrane protein, which plays a major role in phospholipid homeostasis by regulating cholesterol efflux from the cell. ABCA1 antibody studies have shown ABCA1 expression is up/down regulated by the transcription factorsLXR and SREBP2 respectively.
E3 ubiquitin ligases are standards in most antibody catalogs. These proteins are essential to the process of ubiquitination, which is expressed in protein pathways throughout the body and is often linked to disease states. It is widely used as a biomarker, with ubiquitin antibodies being widely used to identify the protein accumulations (inclusion bodies) which occur in conditions such as Alzheimer’s, Parkinson’s and Huntington's disease.
A large percentage of the products in our antibody catalog are used for cancer research. Some oncogenes are expressed in several types of tumor, while others are quite specific. For example, there are several products on our antibody database which target genes specific to nasopharyngeal carcinomas (NPC), such as UBAP1 and MMP9. Recently, a Chinese cancer study, which used no fewer than 10,000 volunteer subjects, uncovered 3 new susceptibility genes for NPC.
Death-receptor apoptosis, or cell death, is essential for cellular growth regulation; its disruption is expressed in a variety of cancers. We at Novus Biologicals are one of the leading antibody suppliersfor apoptosis and cancer research groups, and therefore have a large antibody database targeting death receptor proteins.
A large number of antibody assays are devoted to the study of nuclear excision repair (NER) proteins. However, there are a number of other DNA repair pathways, many of which are instigated by NER and share the same proteins. DNA repair antibodies are widely used in cancer research, and Novus Biologicals offers an extensive selection of thoroughly validated, high-quality DNA repair and cancer related antibodies.
A large number of antibody suppliers supply conjugated and non-conjugated marker antibodies, targeted at specific stem cell populations. Until recently the number of oval stem cell markers was extremely limited. However, we at Novus Biologicals have succeeded in developing a new line of monoclonal antibodies specifically targeted to the murine oval cell response. These have just been added to our stem cell antibody database.
The Bestrophin 1 to 4 group of proteins are membrane-bound globulins, encoded by the BEST genes 1 to 4. We at Novus Biologicals have a range of products for Best research on our antibody database; mainly targeted to Best-1.
Antibody studies into human CHARGE syndrome have shown mutated CHD7 plays a major role in its development. CHARGE originates in neural crest cells (NCCs) during early embryonic development. It leads to a number of birth defects including craniofacial, heart, brain, urogenital, hearing and growth defects. New research conducted by Wysocka et al, of the Stamford University School of Medicine, indicates a connection with tumour development in adults.
The recently discovered FTO (Fat mass and obesity orientated) gene is of great interest to antibody research groups, throwing clearer insight into the reasons why some people have difficulty losing weight, even when following a healthy lifestyle.