Antibody catalog

Embryonic stem cells, embryonic germ cells and teratocarcinoma stem cells are fundamental to understanding early embryo development and differentiation. Therefore, antibodies to embryonic cell surface antigens have emerged as powerful tools for characterizing the function and expression of developmentally regulated cells during both embryogenesis and oncogenesis.

Ischemic cardiovascular disease is the leading cause of death for both men and women in the US and most other industrialized countries. Most commonly caused by atherosclerosis of the coronary arteries, ischemic cardiovascular disease is characterized by a reduced blood supply to the heart, leading to low oxygen, glucose, and pH levels.

Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide (www.parkinsons.org). The prevalence of Parkinson's disease is expected to grow considerably as the average age of the population in developed countries increases.  Despite the hundreds of millions of dollars devoted annually to Parkinson's research, there is relatively little known about the disease and its treatment.

Novus Biologicals is one of the leading antibody suppliers of high affinity human epitope tag reagents, such as the HA tag antibody. Widely used in Western blot, ELISA and Immunohistochemistry assays, they offer a useful and reliable method for detecting, analyzing and purifying proteins from a wide range of species.

In rodents, MAP1LC3 (Microtubule-associated protein 1 light chain 3) is expressed in the renal visceral epithelial cells, or podocytes. LC3 antibody analysis has shown the protein accumulates in its membrane-bound form, LC3II, following conversion from LC3I.

MMP2 antibodies have proven to be important tools for cancer research and extracellular matrix studies. Novus Biologicals offers an excellent MMP2 antibody (Catalog Number NB200-114) for Western blot, immunoprecipitation, ELISA, and immunohistochemical/immunofluorescence staining in human, mouse and rat samples. Originally developed in 2005, this MMP-2 clone (8B4) has been thoroughly characterized and cited in a growing number of published journal articles.

Caspase 3 is a member of the cysteine-aspartic acid protease family and an important mediator of apoptosis. Caspase 3 antibody reagents have been used in cancer, Alzheimer's disease and stem cell research. A recent caspase 3 antibody ELISA study showed elevated levels of the p17 caspase 3 fragment were associated with myocardial infarction in humans.

The ATP Binding Cassette Transporter (ABCA1) gene encodes the cholesterol regulatory efflux protein, which plays a key role in lipid metabolism. ABCA1 antibody products are an important part of any antibody catalog covering atherosclerosis disease research.

Tumor Necrosis Factor alpha (TNFa) is a cytokine protein that plays an essential role in inducing the systemic inflammatory response, being expressed in tissues throughout the body. In autoimmune diseases such as rheumatoid arthritis and psoriasis, TNF alpha causes negative clinical effects. These can be controlled by inhibitory TNF antibody drugs, a number of which are now on the market. We at Novus Biologicals have an extensive range of TNF alpha antibodies.

Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other proteins, including BRCA1 and BRCA2, to effect homologous recombination at double-strand breaks.