Embryonic Stem Cell Marker Antibodies Facilitate Differentiation Studies

Wed, 03/16/2011 - 14:53


Embryonic stem cells, embryonic germ cells and teratocarcinoma stem cells are fundamental to understanding early embryo development and differentiation. Therefore, antibodies to embryonic cell surface antigens have emerged as powerful tools for characterizing the function and expression of developmentally regulated cells during both embryogenesis and oncogenesis.

SSEA3 and TRA-1-60 are cell-surface proteins, involved in cell differentiation, that serve as useful embryonic stem cell markers. SSEA3 is a carbohydrate moietiy epitope of a unique globo-series ganglioside, associated with a variety of cell surface glycopeptides. TRA-1-60 is associated with a pericellular matrix proteoglycan. SSEA-3 and TRA-1-60 are both expressed on the surface of human teratocarcinoma stem cells, human embryonic germ cells and human embryonic stem cells.

Immunocytochemistry/Immunofluorescence: SSEA3 Antibody

Novus Biologicals offers excellent marker antibodies to both SSEA3 (catalog number NB100-1832) and TRA-1-60(R) (catalog number NB100-730). Our lab has recently released new immunofluorescent cytochemistry staining data on human embryonic stem cell lines demonstrating SSEA3 and TRA-1-60 surface expression patterns. Additionally, both antibodies have previously been validated in FACS analysis by Matin, et al.

Browse our complete list of embryonic stem cell marker antibodies, proteins, lysates and more.

 


Blog Topics


Archives