FUS Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

The protein originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-50623	Applications	Species
Kirby J, Highley JR, Cox L et al. Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation. Neuropathol Appl Neurobiol 2013-08-01 [PMID: 23228179] (IHC-P, Human)	IHC-P	Human
Mitchell JC, McGoldrick P, Vance C et al. Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion Acta Neuropathol 2012-09-09 [PMID: 22961620] (WB, Mouse)	WB	Mouse

Array NBP1-50623

• FUS Antibodies
• FUS ELISA Kits
• FUS Lysate
• FUS Proteins