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Aggrecan Antibody

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Summary
Product Discontinued
View other related Aggrecan Primary Antibodies

Order Details


    • Catalog Number
      NBP1-71370
    • Availability
      Product Discontinued

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Aggrecan Antibody Summary

Immunogen
The antiserum was produced against synthesized peptide derived from human Aggrecan. The immunogen region is: N-terminal.
Marker
Chondrocyte Marker
Specificity
Aggrecan (Cleaved-Asp369) Antibody detects endogenous levels of fragment of activated Aggrecan resulting from cleavage adjacent to Asp369.
Clonality
Polyclonal
Host
Rabbit
Gene
ACAN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:20000
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Western Blot 1:500-1:1000
Theoretical MW
44 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP1-71370.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Aggrecan Antibody

  • ACAN
  • AGC1
  • AGC1SEDK
  • aggrecan core protein
  • Aggrecan
  • Cartilage-specific proteoglycan core protein
  • Chondroitin sulfate proteoglycan 1
  • Chondroitin sulfate proteoglycan core protein 1
  • CSPCP
  • CSPG1
  • CSPG1aggrecan 1
  • CSPGCP
  • large aggregating proteoglycan
  • MSK16
  • MSK16AGCAN
  • SEDK

Background

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Aggrecan Antibody
NBP1-71370
Aggrecan Antibody
Species: Hu, Rt
Applications: WB, ELISA, IHC

Publications for Aggrecan Antibody (NBP1-71370)(1)

We have publications tested in 1 application: WB.


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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Research Areas for Aggrecan Antibody (NBP1-71370)

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Blogs on Aggrecan.

Check out the latest blog posts on Aggrecan.
Aches & Pains: Aggrecan in Joint Disease and Osteoarthritis
Aggrecan is essential for the normal function of articular cartilage and intervertebral discs. Aggrecan provides the ability for the tissues to withstand compressive loading. This property is dependent on both the high charge density endowed by its nu...  Read full blog post.

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Bioinformatics

Gene Symbol ACAN
Entrez
OMIM
Uniprot