YM1/Chitinase 3-like 3 Antibody [Biotin]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

YM1/Chitinase 3-like 3 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse YM1/Chitinase 3-like 3
  Tyr22-Tyr398
  Accession # O35744
• Specificity: Detects mouse YM1/Chitinase 3-like 3 in Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: Chil3
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for YM1/Chitinase 3-like 3 Antibody [Biotin]

• AI505981
• CHI3L3
• Chitinase 3 like 3
• Chitinase 3-like 3
• ECF-L
• YM1

Background

ECF-L, also known as YM1, is a secreted 377 amino acid residue lectin that binds heparin and G1cN oligomers. It is produced primarily by macrophages during inflammation. ECF-L shares homology with chitinase family proteins but lacks enzymatic activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for YM1/Chitinase 3-like 3 Antibody (BAF2446)(12)

Publications using BAF2446

• Chang, KW;Wang, LC;Wang, HY;Lin, TY;Hwu, EE;Cheng, PC; Inflammatory and immunopathological differences in brains of permissive and non-permissive hosts with Angiostrongylus cantonensis infection can be identified using 18F/FDG/PET-imaging PLoS neglected tropical diseases 2024-05-28 [PMID: 38805557] (Immunohistochemistry, Mouse, Rat)
• Ajendra, J;Papotto, PH;Parkinson, JE;Dodd, RJ;Bombeiro, AL;Pearson, S;Chan, BHK;Ribot, JC;McSorley, HJ;Sutherland, TE;Allen, JE; The IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration Mucosal immunology 2023-09-30 [PMID: 37783278] (Immunohistochemistry, Mouse)
• Christina Draijer, Laura Florez-Sampedro, Catharina Reker-Smit, Eduard Post, Fransien van Dijk, Barbro N. Melgert Explaining the polarized macrophage pool during murine allergic lung inflammation Frontiers in Immunology 12/20/2022 [PMID: 36605195]
• J Peng, CB Sy, JJ Ponessa, AD Lemenze, CM Hernandez, JM Inclan-Ric, A Sawhney, HG Federman, K Chavan, V Espinosa, SV Kotenko, A Rivera, MC Siracusa Monocytes maintain central nervous system homeostasis following helminth-induced inflammation Proceedings of the National Academy of Sciences of the United States of America, 2022-09-07;119(37):e2201645119. 2022-09-07 [PMID: 36070344] (ICC, Mouse)
• HJ Shin, KY Lee, JW Kang, SG Choi, DW Kim, YY Yi Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model International Journal of Nanomedicine, 2022-06-27;17(0):2791-2804. 2022-06-27 [PMID: 35782016] (Western Blot, Rat)
• Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rückerl Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity Frontiers in Immunology 7/27/2021 [PMID: 34386014]
• TE Sutherland, D Rückerl, N Logan, S Duncan, TA Wynn, JE Allen Ym1 induces RELM? and rescues IL-4R? deficiency in lung repair during nematode infection PLoS Pathog., 2018-11-30;14(11):e1007423. 2018-11-30 [PMID: 30500858] (Flow Cytometry, Mouse)
• LR Hoving, HJP van der Za, A Pronk, B Guigas, K Willems va, V van Harmel Dietary yeast-derived mannan oligosaccharides have immune-modulatory properties but do not improve high fat diet-induced obesity and glucose intolerance PLoS ONE, 2018-05-03;13(5):e0196165. 2018-05-03 [PMID: 29723205] (Flow Cytometry, Mouse)
• Z Czimmerer, B Daniel, A Horvath, D Rückerl, G Nagy, M Kiss, M Peloquin, MM Budai, I Cuaranta-M, Z Simandi, L Steiner, B Nagy, S Poliska, C Banko, Z Bacso, IG Schulman, S Sauer, JF Deleuze, JE Allen, S Benko, L Nagy The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages Immunity, 2018-01-16;48(1):75-90.e6. 2018-01-16 [PMID: 29343442] (Flow Cytometry, Mouse)
• Zhang W, Zheng X, DU L, Sun J, Shen Z, Shi C, Sun S, Zhang Z, Chen X, Qin M, Liu X, Tao J, Jia L, Fan H, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan S High salt primes a specific activation state of macrophages, M(Na). Cell Res, 2015-07-24;25(8):893-910. 2015-07-24 [PMID: 26206316] (Western Blot, Mouse)
• Mills Ko E, Ma J, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika A, Pleasure D Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation, 2014-06-12;11(0):105. 2014-06-12 [PMID: 24924222] (Flow Cytometry, Mouse)
• Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika A, Pleasure D Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci, 2014-06-11;34(24):8175-85. 2014-06-11 [PMID: 24920622] (Flow Cytometry, Mouse)

Review for YM1/Chitinase 3-like 3 Antibody (BAF2446) (1)

Average Rating: 5

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Verified Customer Flow Mouse 01/12/2015

Summary

• Application: Flow Cytometry
• Sample Tested: See PMID 24101381
• Species: Mouse

Bioinformatics

• Gene Symbol: Chil3
• Uniprot:
  • O35744()