XBP1 Antibody Summary
The immunogen for this antibody was a sequence from 1a.a. to 74a.a. from XBP1(a 261a.a. long protein)
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Western Blot 1:100-1:2000
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
This antibody is reactive against Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Alternate Names for XBP1 Antibody
- X-box binding protein 1
- X-box-binding protein 1
- XBP2Tax-responsive element-binding protein 5
This protein is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This protein product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. Adding to the list of functional possibilities is a recent report from studies of knockout mice showing that this gene is essential for hepatocyte growth. A pseudogene has been identified and localized to chromosome 5.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Positive Control Lysate(s)
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