WHSC1 Antibody - Azide and BSA Free

Western Blot: WHSC1 Antibody [H00007468-B01P] - Analysis of WHSC1 expression in Hela S3 NE.

Immunocytochemistry/Immunofluorescence: WHSC1 Antibody [H00007468-B01P] - Analysis of purified antibody to WHSC1 on HeLa cell. (antibody concentration 10 ug/ml)

Western Blot: WHSC1 Antibody [H00007468-B01P] - Analysis of WHSC1 expression in transfected 293T cell line by WHSC1 polyclonal antibody. Lane1:WHSC1 transfected lysate(71.17 KDa). Lane2:Non-transfected lysate.

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

WHSC1 Antibody - Azide and BSA Free Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: WHSC1 (NP_579889.1, 1 a.a. - 647 a.a.) full-length human protein. MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENELLWEPTPVKLDLNPAALYCT
• Specificity: WHSC1 - Wolf-Hirschhorn syndrome candidate 1,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: NSD2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: It has been used for ELISA, WB and IF.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for WHSC1 Antibody - Azide and BSA Free

• EC 2.1.1.43
• FLJ23286
• IL5 promoter REII region-binding protein
• KIAA1090
• MGC176638
• MMSETNSD2Multiple myeloma SET domain-containing protein
• multiple myeloma SET domain containing protein type III
• nuclear receptor binding SET domain protein 2
• Nuclear SET domain-containing protein 2
• probable histone-lysine N-methyltransferase NSD2
• Protein trithorax-5
• REIIBP
• trithorax/ash1-related protein 5
• TRX5
• WHS
• Wolf-Hirschhorn syndrome candidate 1 protein
• Wolf-Hirschhorn syndrome candidate 1

Background

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for WHSC1 Antibody (H00007468-B01P)(2)

Publications using H00007468-B01P

• Jaffe JD, Wang Y, Chan HM et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet. 2013-11-01 [PMID: 24076604]
• Huang Z, Wu H, Chuai S et al. NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma. Cancer Res. 2013-08-26 [PMID: 23980095]

Bioinformatics

• Gene Symbol: NSD2
• Entrez:
  • 7468(Human)
• Uniprot:
  • NP_579889.1(Human)