VSIG2 Antibody (541522) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 541522
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

VSIG2 Antibody (541522) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human VSIG2 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VSIG2 Antibody (541522) [Alexa Fluor™ Plus 647]

• 2210413P10Rik
• Cortical thymocyte-like protein
• CTH
• CTHCTXLcortical thymocyte receptor (X. laevis CTX) like
• CT-like protein
• CTXL
• V-set and immunoglobulin domain containing 2
• V-set and immunoglobulin domain-containing protein 2
• VSIG2

Background

V-set and immunoglobulin domain-containing protein 2 (VSIG2), also known as cortical thymocyte-like protein (CT-like protein), is a member of the immunoglobulin superfamily (Igsf) that was originally described in Xenopus and was referred to as cortical thymocyte marker in Xenopus, or CTX. The clone isolated from the human genomic library was called CTH (1). Mature human VSIG2 is a single-pass type I transmembrane protein with a 220 amino acid (aa) extracellular domain (ECD) that contains one C2-type and one V-type immunoglobulin-like domains, and a 63 aa cytoplasmic region linked to the ECD by a short 21 aa transmembrane domain. Human VSIG2 ECD shares 85% and 86% aa sequence identity with mouse and rat VSIG2, respectively. VSIG2 is structurally related to the B7 family of immune regulatory proteins. Our studies at R&D Systems show that VSIG2 inhibits T cell activation, including IL17 and interferon gamma production.

1. Chrétien, I. et al. (1998) Eur. J. Immunol. 28:4094.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.