Vasorin/SLIT-like 2 Antibody

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Vasorin/SLIT-like 2 Antibody Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Vasorin extracellular domain
• Specificity: Detects human Vasorin in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: VASN
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Vasorin/SLIT-like 2 Antibody

• Atia
• Protein slit-like 2
• SLIT like 2
• Slitl2
• slit-like 2 (Drosophila)
• slit-like 2
• VASN
• Vasorin

Background

Vasorin is a type I membrane protein that is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. Expression is down-regulated during vessel repair after arterial injury. Vasorin directly binds to transforming growth factor (TGF)-beta and attenuates TGF-beta signaling in vitro (1).

1. Ikeda, Y. et al. (2004) Proc. Natl. Acad. Sci. USA 101:10732.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Vasorin/SLIT-like 2 Antibody (AF2140)(1)

Publication using AF2140

• Malapeira J, Esselens C, Bech-Serra JJ, Canals F, Arribas J ADAM17 (TACE) regulates TGFbeta signaling through the cleavage of vasorin. Oncogene, 2010-12-20;30(16):1912-22. 2010-12-20 [PMID: 21170088] (Western Blot, Human)

Bioinformatics

• Gene Symbol: VASN