Vasohibin Antibody [Unconjugated] - Isoform 1

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

Vasohibin Antibody [Unconjugated] - Isoform 1 Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Vasohibin Isoform 1
  Pro2-Val365
  Accession # Q7L8A9
• Specificity: Detects human Vasohibin Isoform 1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: VASH1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Vasohibin Antibody [Unconjugated] - Isoform 1

• KIAA1036
• KIAA1036vasohibin-1
• VASH
• VASH1
• vasohibin 1
• Vasohibin

Background

Vasohibin is a secreted endothelium-derived negative feedback regulator of angiogenesis whose expression in endothelial cells is induced by proangiogenic growth factors such as VEGF and FGF-2. It is synthesized as a 365 amino acid residue protein that lacks a canonical signal peptide. As a result of proteolytic cleavage, multiple distinct molecular weight forms can be detected when Vasohibin is expressed on endothelial cells. Human and mouse Vasohibin share 93% amino acid sequence identity. Two splice variants of human Vasohibin have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Vasohibin Antibody (AF3319)(1)

Publication using AF3319

• Kern J, Bauer M, Rychli K, Wojta J, Ritsch A, Gastl G, Gunsilius E, Untergasser G Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation. Arterioscler. Thromb. Vasc. Biol., 2008-01-10;28(3):478-84. 2008-01-10 [PMID: 18187668] (Western Blot, Human)

Bioinformatics

• Gene Symbol: VASH1
• Uniprot:
  • Q7L8A9()