Vasohibin Antibody (411208)

• Reactivity: Hu
• Applications: WB
• Clone: 411208
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Vasohibin Antibody (411208) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Vasohibin isoform 1
  Pro2-Val365
  Accession # Q7L8A9
• Specificity: Detects human Vasohibin in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: VASH1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Vasohibin Antibody (411208)

• KIAA1036
• KIAA1036vasohibin-1
• VASH
• VASH1
• vasohibin 1
• Vasohibin

Background

Vasohibin is an endothelium-derived negative feedback regulator of angiogenesis. The 365 amino acid (aa), 44 kDa human Vasohibin shows 93% aa identity with mouse Vasohibin. Vasohibin has no canonical signal sequence, but the full-length form is only associated with cells, while N-terminally cleaved, active 42 kDa and 36 kDa forms are both cell-associated and secreted. Minor amounts of C-terminally cleaved 27 kDa form are inactive and lack the C-terminal heparin-binding basic domain. Vasohibin expression is upregulated by VEGF and FGF‑2, but this can be modulated by IL-1, TNF‑ alpha , or IFN‑ gamma .

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VASH1
• Uniprot:
  • Q7L8A9()