Vang-like Protein 2/VANGL2 Antibody

Western Blot: Vang-like Protein 2/VANGL2 Antibody [NBP2-24704] - Analysis of Van Gogh like-2 in human brain lysate in the 1) absence and2) presence of immunizing peptide, 3) mouse brain and 4) rat brain using this antibody. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Immunohistochemistry-Paraffin: Vang-like Protein 2/VANGL2 Antibody [NBP2-24704] - Analysis of Van Gogh like-2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.

• Reactivity: Hu, Mu, Rt, Bv, Ca, Pm
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Vang-like Protein 2/VANGL2 Antibody Summary

• Description: Novus Biologicals Rabbit Vang-like Protein 2/VANGL2 Antibody (NBP2-24704) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A portion of amino acids 300-350 of human Van Gogh like-2 protein was used as the immunogen.
• Specificity: 100% homologous in human isoform CRA_a, CRA_b and CRA_c).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VANGL2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot 4-6 ug/ml

Reactivity Notes

Chimpanzee (100%), Opossum, Equine (93%), Chicken, Xenopus (73%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for Vang-like Protein 2/VANGL2 Antibody

• KIAA1215Loop-tail protein 1 homolog
• loop-tail-associated protein
• LPP1
• LTAP
• LTAPVan Gogh-like protein 2
• MGC119403
• MGC119404
• STB1
• STB1Strabismus 1
• STBM
• STBM1
• Strabismus
• vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)
• Vang like Protein 2
• VANGL2
• vang-like 2 (van gogh, Drosophila)
• Vang-like Protein 2

Background

VANGL2 is involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. It is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. The VANGL2 gene encodes a homolog of Drosophila 'strabismus/Van Gogh' (Stbm/Vang), a component of the frizzled-dishevelled tissue polarity pathway.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VANGL2