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HAF016). A specific band was detected for Vang-like Protein 2/VANGL2 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
CTS019) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling when primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. Specific staining was localized to developing spinal cord. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
VANGL2 is involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. It is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. The VANGL2 gene encodes a homolog of Drosophila 'strabismus/Van Gogh' (Stbm/Vang), a component of the frizzled-dishevelled tissue polarity pathway.[supplied by OMIM]
![Western Blot Vang-like Protein 2/VANGL2 [p Ser84, p Ser79, p Ser82] Antibody (6O6T6)](http://images.novusbio.com/fullsize/Vang-like-Protein-2-VANGL2-p-Ser84-p-Ser79-p-Ser82-Antibody-5N5B3-Western-Blot-NBP3-16947-img0001.jpg)
![Western Blot Vang-like Protein 2/VANGL2 [p Ser84, p Ser79, p Ser82] Antibody (6O6T6)](http://images.novusbio.com/fullsize/nbp3-16947_rabbit-vang-like-protein-2-vangl2-p-ser-79-p-ser-82-p-ser-84-mab-6o6t6-5220251255522.jpg)
