Vang-like Protein 2/VANGL2 Products

Description

VANGL2 is involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. It is required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. The VANGL2 gene encodes a homolog of Drosophila 'strabismus/Van Gogh' (Stbm/Vang), a component of the frizzled-dishevelled tissue polarity pathway.[supplied by OMIM]

Bioinformatics

Entrez	57216 Human 93840 Mouse
Uniprot	Q9ULK5 Human NP_065068 Human NP_065068.1 Human
Product By Gene ID	57216
Alternate Names	STBM vang-like protein 2 MGC119404 loop-tail-associated protein MGC119403 vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila) LPP1 LTAPVan Gogh-like protein 2 STB1Strabismus 1 KIAA1215Loop-tail protein 1 homolog STBM1 vang-like 2 (van gogh, Drosophila)

Diseases related to Vang-like Protein 2/VANGL2

Discover more about diseases related to Vang-like Protein 2/VANGL2.

Strabismus
Malignant Neoplasms
Congenital Abnormality
Neoplasms
Spina Bifida
Tissue Adhesions
Carcinogenesis
Congenital Heart Defects
Malignant Neoplasm Of Stomach
Neoplasm Metastasis
Melanoma
Cystic Kidney Diseases
Cell Invasion
Exencephaly
Double Outlet Right Ventricle
Robinow Syndrome
Hydrocephalus
Malignant Neoplasm Of Lung
Nervousness

Pathways for Vang-like Protein 2/VANGL2

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Convergent Extension
Neural Tube Closure
Tube Closure
Gastrulation
Localization
Cell Migration
Cell Division
Regeneration
Cell Adhesion
Axon Guidance
Tube Formation
Neuron Migration
Cell Motility
Neural Tube Formation
Neurogenesis
Cell Growth
Cell Differentiation
Pathogenesis
Transport
Embryonic Morphogenesis

PTMs for Vang-like Protein 2/VANGL2

Learn more about PTMs related to Vang-like Protein 2/VANGL2.

Phosphorylation
Acetylation

Bioinformatics Tool for Vang-like Protein 2/VANGL2

Discover related pathways, diseases and genes to Vang-like Protein 2/VANGL2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.