Vang-like Protein 2/VANGL2 Antibody [Alexa Fluor® 750]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

Vang-like Protein 2/VANGL2 Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Vang-like Protein 2/VANGL2
  Gln241-Val521
  Accession # Q9ULK5
• Specificity: Detects human, mouse, and rat Vang-like Protein 2/VANGL2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human VANGL1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Vang-like Protein 2/VANGL2 Antibody [Alexa Fluor® 750]

• KIAA1215Loop-tail protein 1 homolog
• loop-tail-associated protein
• LPP1
• LTAP
• LTAPVan Gogh-like protein 2
• MGC119403
• MGC119404
• STB1
• STB1Strabismus 1
• STBM
• STBM1
• Strabismus
• vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)
• Vang like Protein 2
• VANGL2
• vang-like 2 (van gogh, Drosophila)
• Vang-like Protein 2

Background

VANGL2 (van Gogh-like protein 2; also Strabismus and Ltap) is a 65 kDa member of the Vang family of proteins. It is found in the membranes of embryonic neurons and epithelium where it associates with DVL1-3 and various frizzleds. VANGL2 mutations are associated with neural tube defects. Human VANGL2 is a 521 amino acid (aa) 4-transmembrane protein that contains an N-terminal (aa 1‑108) and C-terminal (aa 239‑521) cytoplasmic domain. There is a Ser-rich region in the N-terminus (aa 5‑20) and a PDZ-binding motif over aa 506‑521. Over aa 241‑521, human, mouse and rat show total identity in amino acid sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.