Uromodulin Antibody (10.32) [FITC]

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Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) [FITC] [NBP1-50431] - Analysis of anti-UMOD / Uromodulin antibody with human kidney at dilution 1:50.

Product Details

Summary
Reactivity Hu, CaSpecies Glossary
Applications ELISA, ICC/IF, IHC-Fr, IHC-P
Clone
10.32
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC
Concentration
0.1 mg/ml

Order Details

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Catalog# & Conjugate Size Price

Uromodulin Antibody (10.32) [FITC] Summary

Immunogen
Human Tamm-Horsfall protein.
Specificity
Anti-human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kD containing up to 25% carbohydrate by weight.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
UMOD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 1:50
Application Notes
For IHC-Paraffin, use heat induced antigen retrieval in pH 6.0 citrate buffer.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and EIA grade BSA
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein G purified

Alternate Names for Uromodulin Antibody (10.32) [FITC]

  • ADMCKD2
  • FJHN
  • HNFJ
  • HNFJ1
  • MCKD2
  • Tamm-Horsfall glycoprotein
  • Tamm-Horsfall urinary glycoprotein
  • THGP
  • THP
  • UMOD
  • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
  • Uromodulin
  • Uromucoid

Background

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol UMOD
Entrez