Uromodulin Products

Antibodies
Uromodulin Antibody
Uromodulin Antibody
AF5144
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Uromodulin Antibody (774056)
Uromodulin Antibody (774056)
MAB5175
Species: Mu
Applications: WB, IHC
Host: Rat Monoclonal
Uromodulin Antibody
Uromodulin Antibody
AF5175
Species: Mu
Applications: WB, IHC
Host: Sheep Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
Uromodulin Antibody Pair
Uromodulin Antibody Pair
H00007369-PW1
Species: Hu
Applications: WB, IP
Uromodulin Antibody Pair
Uromodulin Antibody Pair
H00007369-PW2
Species: Hu
Applications: WB, IP
Lysates
Uromodulin Overexpression Lys ...
Uromodulin Overexpression Lysate (...
H00007369-T01
Species: Hu
Applications: WB
Uromodulin Overexpression Lys ...
Uromodulin Overexpression Lysate (...
H00007369-T02
Species: Hu
Applications: WB
Proteins
Uromodulin Partial Recombinan ...
Uromodulin Partial Recombinant Pro...
H00007369-Q01
Species: Hu
Applications: WB, ELISA, PA
Uromodulin Recombinant Protei ...
Uromodulin Recombinant Protein Ant...
NBP2-33730PEP
Species: Hu
Applications: AC
Uromodulin Recombinant Protei ...
Uromodulin Recombinant Protein Ant...
NBP2-33393PEP
Species: Hu
Applications: AC
RNAi
Uromodulin RNAi
Uromodulin RNAi
H00007369-R02
Species: Hu
Applications: RNAi, RNAi SP
Uromodulin RNAi
Uromodulin RNAi
H00007369-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Uromodulin encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7369
Alternate Names
  • HNFJ1
  • uromucoid
  • FJHN
  • Tamm-Horsfall glycoprotein
  • ADMCKD2
  • THGP
  • THP
  • Tamm-Horsfall urinary glycoprotein
  • HNFJ
  • uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
  • MCKD2
  • uromodulin

Research Areas for Uromodulin

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Cell Cycle and Replication

Bioinformatics Tool for Uromodulin

Discover related pathways, diseases and genes to Uromodulin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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