After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.
HAF016). A specific band was detected for Uromodulin at approximately 115 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
NL010) and counterstained with DAPI (blue). Specific staining was localized to convoluted tubule epithelial cells. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
HAF005). A specific band was detected for Uromodulin at approximately 115 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8." class="big_lightbox" target="_blank">
NL013) and counterstained with DAPI (blue). Specific staining was localized to convoluted tubule epithelial cells. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank">
HAF016). A specific band was detected for Uromodulin at approximately 80-90 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
Uromodulin encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]
![Western Blot Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Uromodulin_AF5175_Western_Blot_5648.jpg)
![Western Blot Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Uromodulin_AF5144_Western_Blot_13143.jpg)
![N/A Uromodulin [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_Uromodulin_DY514405_ELISA_2472.jpg)
![Immunohistochemistry Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Uromodulin_AF5175_Immunohistochemistry_12099.jpg)
![Simple Western Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af5175_mouse-uromodulin-affinity-purified-polyclonal-ab-simple-western-2382024141529..jpg)
![Immunocytochemistry/ Immunofluorescence Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5175_mouse-uromodulin-affinity-purified-polyclonal-ab-41202410481117.jpg)
![Immunohistochemistry Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5175_mouse-uromodulin-affinity-purified-polyclonal-ab-4120241240233.jpg)
![Immunohistochemistry Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5175_mouse-uromodulin-affinity-purified-polyclonal-ab-41202412401214.jpg)
![Simple Western Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af5144_human-uromodulin-affinity-purified-polyclonal-ab-simple-western-25102024131229..jpg)
![Immunohistochemistry Uromodulin Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Uromodulin_AF5144_Immunohistochemistry_6864.jpg)
