UPF3A Antibody (2E2)

Images

 
Western Blot: UPF3A Antibody (2E2) [H00065110-M06] - Analysis of UPF3A expression in transfected 293T cell line by UPF3A monoclonal antibody (M06), clone 2E2. Lane 1: UPF3A transfected lysatE (51 KDa). Lane 2: ...read more
Immunohistochemistry-Paraffin: UPF3A Antibody (2E2) [H00065110-M06] - Analysis of monoclonal antibody to UPF3A on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 3 ug/ml
Sandwich ELISA: UPF3A Antibody (2E2) [H00065110-M06] - Detection limit for recombinant GST tagged UPF3A is 0.03 ng/ml as a capture antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clone
2E2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

UPF3A Antibody (2E2) Summary

Immunogen
UPF3A (AAH23569, 274 a.a. ~ 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
UPF3A - UPF3 regulator of nonsense transcripts homolog A (yeast) (2E2)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
UPF3A
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for UPF3A Antibody (2E2)

  • HUPF3A
  • Nonsense mRNA reducing factor 3A
  • regulator of nonsense transcripts 3A
  • RENT3AUp-frameshift suppressor 3 homolog A
  • UPF3 regulator of nonsense transcripts homolog A (yeast)
  • UPF3hUpf3

Background

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol UPF3A
Entrez
Uniprot