UPF3A Products

Description

UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	65110 Human
Uniprot	NP_075387 Human NP_075387.1 Human NP_542418.1 Human Q9H1J1 Human AAH23569 Human AAH23569.1 Human
Product By Gene ID	65110
Alternate Names	regulator of nonsense transcripts 3A HUPF3A UPF3hUpf3 RENT3AUp-frameshift suppressor 3 homolog A Nonsense mRNA reducing factor 3A UPF3 regulator of nonsense transcripts homolog A (yeast)

Diseases related to UPF3A

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Impacted Tooth
Genetic Diseases, Inborn

Pathways for UPF3A

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Translation
Rna Surveillance
Reverse Transcription
Translational Termination
Neurogenesis
Nuclear Export

PTMs for UPF3A

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Phosphorylation

Bioinformatics Tool for UPF3A

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