UPF3A Products

Description

UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	65110 Human
Uniprot	AAH23569 Human AAH23569.1 Human NP_075387 Human NP_075387.1 Human NP_542418.1 Human Q9H1J1 Human
Product By Gene ID	65110
Alternate Names	HUPF3A Nonsense mRNA reducing factor 3A regulator of nonsense transcripts 3A RENT3AUp-frameshift suppressor 3 homolog A UPF3 regulator of nonsense transcripts homolog A (yeast) UPF3hUpf3