UGRP1/SCGB3A2 Antibody [Unconjugated]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

UGRP1/SCGB3A2 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human UGRP1/SCGB3A2
  Phe22-Val93
  Accession # Q96PL1
• Specificity: Detects human UGRP1/SCGB3A2 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant mouse UGRP1 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SCGB3A2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for UGRP1/SCGB3A2 Antibody [Unconjugated]

• LU103
• Pneumo secretory protein 1
• PnSP-1
• PNSP1secretoglobin family 3A member 2
• SCGB3A2
• secretoglobin, family 3A, member 2
• UGRP1
• UGRP1pnSP-1
• Uteroglobin-related protein 1

Background

UGRP-1, also known as secretoglobin family 3A member 2 (SCGB3A2) and High in Normal 2 (HIN-2), is a secreted, 38 kDa, homodimeric protein that is highly expressed in epithelial cells of the airway. UGRP-1 has been shown to bind MARCO (macrophage scavenger receptor with collagenous structure), which is expressed by alveolar macrophages. UGRP1 has been suggested to play a role in lung inflammation. Mature human UGRP1 shares 88% and 81% amino acid sequence identity with rat and mouse mature UGRP1, respectively. Mature UGRP-1 is also 53% identical with that of human mature UGRP-2 (HIN-1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for UGRP1/SCGB3A2 Antibody (AF3545)(3)

Publications using AF3545

• Lv, Z;Liu, Z;Liu, K;Lin, X;Pu, W;Li, Y;Zhao, H;Xi, Y;Sui, P;Vaughan, AE;Gillich, A;Zhou, B; Alveolar regeneration by airway secretory-cell-derived p63+ progenitors Cell stem cell 2024-08-30 [PMID: 39232560] (Immunohistochemistry, Mouse)
• P Kadur Laks, V Sontake, A Tata, Y Kobayashi, L Macadlo, K Okuda, AS Conchola, S Nakano, S Gregory, LA Miller, JR Spence, JF Engelhardt, RC Boucher, JR Rock, SH Randell, PR Tata Human distal lung maps and lineage hierarchies reveal a bipotent progenitor Nature, 2022-03-30;604(7904):111-119. 2022-03-30 [PMID: 35355018]
• Mart M Lamers, Jelte van der Vaart, Kèvin Knoops, Samra Riesebosch, Tim I Breugem, Anna Z Mykytyn et al. An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells The EMBO Journal 2021-03-01 [PMID: 33283287]

Bioinformatics

• Gene Symbol: SCGB3A2
• Uniprot:
  • Q96PL1()