TTF-1 / NKX2-1 Antibody (NX2.1/690)

Images

 
Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (NX2.1/690) [NBP2-44500] - Human Thyroid stained with TTF-1 Monoclonal Antibody (NX2.1/690)
Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (NX2.1/690) [NBP2-44500] - Human Lung Adenocarcinoma stained with TTF-1 Monoclonal Antibody (NX2.1/690)
Immunohistochemistry-Paraffin: TTF1 / NKX2.1 Antibody (NX2.1/690) [NBP2-44500] - Rat Lung stained with TTF-1 Monoclonal Antibody (NX2.1/690)

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, IHC-P, ICC/IF
Clone
NX2.1/690
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

TTF-1 / NKX2-1 Antibody (NX2.1/690) Summary

Immunogen
Recombinant TTF-1 protein
Localization
Nuclear
Marker
Thyroid & Lung Epithelial Marker
Specificity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
NKX2-1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml
  • Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml
  • Immunofluorescence 0.5 - 1.0 ug/ml
Application Notes
Hu-chromosome location: 14q13.3
Immunohistochemistry-Paraffin 0.5 - 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at RT for 20 minutes.
Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for TTF-1 / NKX2-1 Antibody (NX2.1/690)

  • BCH
  • benign chorea
  • BHC
  • Homeobox protein NK-2 homolog A
  • homeobox protein Nkx-2.1
  • NK2 homeobox 1
  • NK-2 homolog A
  • NKX2.1
  • NKX2-1
  • NKX2A
  • NKX2ANKX2.1
  • T/EBP
  • Thyroid nuclear factor 1
  • Thyroid transcription factor 1BHC
  • TITF1
  • TITF1TEBP
  • TTF1
  • TTF-1
  • TTF1BCH
  • TTF-1NK-2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol NKX2-1
Uniprot