TTF-1 / NKX2-1 Products

Antibodies
TTF-1 / NKX2-1 Antibody (2054 ...
TTF-1 / NKX2-1 Antibody (2054E) [U...
MAB94581
Species: Hu
Applications: WB, IHC, ICC/IF
Host: Rabbit Monoclonal
Formulation Catalog # Availability Price  
Lysates
TTF-1 / NKX2-1 Overexpression ...
TTF-1 / NKX2-1 Overexpression Lysate
NBL1-13658
Species: Hu
Applications: WB
TTF-1 / NKX2-1 Overexpression ...
TTF-1 / NKX2-1 Overexpression Lysate
NBP2-10635
Species: Hu
Applications: WB
TTF-1 / NKX2-1 Overexpression ...
TTF-1 / NKX2-1 Overexpression Lysate
NBP2-11446
Species: Hu
Applications: WB
Proteins
Recombinant Human TTF-1 / NKX ...
Recombinant Human TTF-1 / NKX2-1 P...
H00007080-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Recombinant Human TTF-1 / NKX ...
Recombinant Human TTF-1 / NKX2-1 P...
H00007080-Q01
Species: Hu
Applications: WB, ELISA, PA, AP

Description

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype (1). Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000 newborns. Mutations in PAX8, TTF1, or FOXE1 may account for congenital hypothyroidism in patients with either isolated TD or TD with associated malformations involving kidney, lung, forebrain, and palate (2). In addition to its presence in thyroid gland epithelium, the human TTF-1 protein was detected by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the nuclei of epithelial cells of the developing airways. After birth, TTF-1 was selectively expressed in Type II epithelial cells in the alveoli and in subsets of bronchiolar epithelial cells in the conducting regions of the lung (3).

Bioinformatics

Entrez Human
Mouse
Mouse
Mouse
Rat
Rat
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 7080
Alternate Names
  • TTF1
  • NK-2 homolog A
  • Thyroid nuclear factor 1
  • homeobox protein Nkx-2.1
  • Homeobox protein NK-2 homolog A
  • TITF1TEBP
  • NKX2ANKX2.1
  • TTF-1NK-2
  • Thyroid transcription factor 1BHC
  • TTF1BCH
  • benign chorea
  • NK2 homeobox 1

Research Areas for TTF-1 / NKX2-1

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones

PTMs for TTF-1 / NKX2-1

Learn more about PTMs related to TTF-1 / NKX2-1.

Methylation
Phosphorylation
Demethylation
Acetylation

Bioinformatics Tool for TTF-1 / NKX2-1

Discover related pathways, diseases and genes to TTF-1 / NKX2-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.