Reactivity | HuSpecies Glossary |
Applications | WB, Flow, CyTOF-ready, ICC/IF |
Clone | 458811 |
Clonality | Monoclonal |
Host | Rat |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | NS0 mouse myeloma cell line transfected with human TSPAN8 Met1-Lys237 (Ile35Val) Accession # AAH05246 |
Specificity | Detects human TSPAN8 in Western blots. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Rat |
Gene | TSPAN8 |
Purity Statement | Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Concentration | LYOPH |
Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
Tetraspanin-8 (TSPAN8), also known as TM4SF3 and human tumor-associated antigen CO-0029, is a member of the transmembrane 4 superfamily. It is a cell surface 27‑34 kDa glycoprotein with 4 transmembrane segments, and a large extracellular loop (LEL) domain from amino acids (aa) 106‑206. Both the N- and C-termini are intracellular. TSPAN8 is expressed by multiple tumor types as well as smooth and skeletal muscle cells, endothelial cells, hematopoietic progenitor cells and non-keratinized squamous epithelium. As with other TSPAN family molecules, TSPAN8 acts as an organizer of microdomains in membranes. Molecules that may be found in these domains include CD151 (another TSPAN family member), beta 1 Integrins, Integrin alpha 4 beta 6, EpCAM, and CD13. TSPAN8 would appear to remove Integrins from the cell surface, facilitating cell motility which, in the case of tumor cells, results in metastasis. TSPAN8 shares 53% aa sequence identity with both mouse and rat TSPAN8.
Secondary Antibodies |
Isotype Controls |
Diseases for TSPAN8/TM4SF3 Antibody (MAB4734)Discover more about diseases related to TSPAN8/TM4SF3 Antibody (MAB4734).
| Pathways for TSPAN8/TM4SF3 Antibody (MAB4734)View related products by pathway.
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PTMs for TSPAN8/TM4SF3 Antibody (MAB4734)Learn more about PTMs related to TSPAN8/TM4SF3 Antibody (MAB4734).
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