Troponin I Type 1 (slow skeletal) Antibody (12F10)

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Order Details


    • Catalog Number
      NB200-431
    • Availability
      Product Discontinued

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Troponin I Type 1 (slow skeletal) Antibody (12F10) Summary

Immunogen
Full length native protein (purified) (Human).
Specificity
Troponin I from human skeletal muscle. Cross-reaction of this with cardiac troponin I is less then 0.05%.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TNNI1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoassay
  • Sandwich ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
Application Notes
Recommended pair for sandwich immunoassay (coating - conjugate): NB200-431 (Coating) - NB200-432 (conjugate)
Control
Troponin T type 1 (slow skeletal) Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for Troponin I Type 1 (slow skeletal) Antibody (12F10)

  • DKFZp451O223
  • slow-twitch isoform
  • SSTNI
  • TNN1
  • troponin I type 1 (skeletal, slow)
  • troponin I, skeletal, slow
  • troponin I, slow skeletal muscle

Background

Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium. This antibody reacts with subunit I of the troponin complex in human myocardium, where it is the only troponin I isotype present. It does not cross-react with troponin I of skeletal muscle cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Troponin I Type 1 (slow skeletal) Antibody (NB200-431)

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Blogs on Troponin I Type 1 (slow skeletal).

Troponin I Type 1 - Find me in your slow-twitch skeletal muscles
Troponin I is part of a heteromeric thin filament regulatory complex that is responsible for modulating skeletal and cardiac muscle contraction. Troponin complex consists of three subunits: troponin I (TnI), troponin T (TnT), and troponin C (TnC). Eac...  Read full blog post.

Omicron Variant Antibodies

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Bioinformatics

Gene Symbol TNNI1
Entrez
Uniprot