Troponin I Type 1 (slow skeletal) Products

Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. (provided by RefSeq)

Bioinformatics

Entrez	21952 Mouse 29388 Rat 7135 Human
Uniprot	AAH12601 Human NM_003281 Human P19237 Human
Product By Gene ID	7135
Alternate Names	DKFZp451O223 slow-twitch isoform SSTNI TNN1 troponin I type 1 (skeletal, slow) troponin I, skeletal, slow troponin I, slow skeletal muscle

Research Areas for Troponin I Type 1 (slow skeletal)

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Cytoskeleton Markers
Stem Cell Markers

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Troponin I Type 1 - Find me in your slow-twitch skeletal muscles Troponin I is part of a heteromeric thin filament regulatory complex that is responsible for modulating skeletal and cardiac muscle contraction. Troponin complex consists of three subunits: troponin I (TnI), troponin T (TnT), and troponin C (TnC). Eac...    Read more.

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