TRIM21/SSA1 Antibody [PerCP]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: PerCP

TRIM21/SSA1 Antibody [PerCP] Summary

• Immunogen: E. coli-derived recombinant human TRIM21
  Met1-Tyr475
  Accession # P19474
• Specificity: Detects human TRIM21 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: TRIM21
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for TRIM21/SSA1 Antibody [PerCP]

• 52 kDa ribonucleoprotein autoantigen Ro/SS-A
• 52 kDa Ro/SSA
• E3 ubiquitin-protein ligase TRIM21
• EC 6.3.2.-
• rhTRIM21
• RNF81
• RNF81RING finger protein 81
• ro(SS-A)
• Ro52
• RO52SS-A
• Sicca syndrome antigen A
• Sjoegren syndrome type A antigen
• Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
• SSA1
• SSA1SSA
• TRIM21
• tripartite motif containing 21,52 kDa Ro protein
• tripartite motif-containing 21
• Tripartite motif-containing protein 21

Background

SSA1 encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRIM21