TRH-degrading Ectoenzyme/TRHDE Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Mu, Rt
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 594

TRH-degrading Ectoenzyme/TRHDE Antibody [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects mouse and rat TRH-degrading Ectoenzyme/TRHDE in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TRH-degrading Ectoenzyme/TRHDE Antibody [Alexa Fluor™ Plus 594]

• EC 3.4.19.6
• FLJ22381
• PAP-II
• PAP-IIthyroliberinase
• PGPEP2
• Pyroglutamyl-peptidase II
• Thyroliberinase
• thyrotropin-releasing hormone degrading enzyme
• thyrotropin-releasing hormone-degrading ectoenzyme
• TRHDE
• TRH-DE
• TRHdegrading Ectoenzyme
• TRH-degrading Ectoenzyme
• TRH-DEthyrotropin-releasing hormone degrading ectoenzyme
• TRH-specific aminopeptidase

Background

TRHDE, also known as pyroglutamyl peptidase II and thyroliberinase, is a metalloprotease that specifically removes pyroglutamate from thyrotropin-releasing hormone, a tripeptide of L-pyroglutamyl-L-histidyl-L-prolineamide. TRH functions as a hypothalamic hypophysiotropic neuropeptide and neurotransmitter/neuromodulator within the central nervous system (1). Inhibitors of TRHDE have potential applications as research and therapeutic agents because TRHDE inactivates TRH (2). TRHDE is a type II transmembrane protein and a soluble form is also present in the serum (1). The recombinant mouse TRHDE corresponds to the ectodomain of the enzyme. Its amino acid sequence is 97% and 95% identical to that of rat and human.

1. Schmitmeier, S. et al. (2002) Eur. J. Biochem. 269:1278.
2. Kelly, J.A. et al. (2005) Biochem. J. 389:569.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.