TRAILR2/TNFRSF10B Antibody

Product Discontinued

TRAILR2/TNFRSF10B Antibody Summary

• Immunogen: Synthetic peptide corresponding to residues surrounding amino acid 372 of mouse DR5 precursor.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFRSF10B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 0.5% BSA and 30% Glycerol, 5mM EDTA
• Preservative: 0.01% Thimerosal
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TRAILR2/TNFRSF10B Antibody

• CD262 antigen
• CD262
• death domain containing receptor for TRAIL/Apo-2L
• Death receptor 5
• DR5
• DR5TRICK2B
• Fas-like protein
• KILLER/DR5
• KILLERapoptosis inducing protein TRICK2A/2B
• TNF-related apoptosis-inducing ligand receptor 2
• TNFRSF10B
• TRAIL R2
• TRAIL receptor 2
• TRAILR2
• TRAIL-R2apoptosis inducing receptor TRAIL-R2
• TRAILR2cytotoxic TRAIL receptor-2
• TRICK2
• TRICK2A
• TRICKB
• tumor necrosis factor receptor superfamily member 10B
• tumor necrosis factor receptor superfamily, member 10b
• tumor necrosis factor receptor-like protein ZTNFR9
• ZTNFR9

Background

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-2). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for TRAILR2/TNFRSF10B Antibody (NBP1-45951)(2)

Publications using NBP1-45951

• Yang SM, Park Yk, Kim JI et al. LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-a, PPAR-g, STAT‑3, FAS, ACC, perilipin A, and AMPk. Int. J. Mol. Med. 2018-09-21 [PMID: 30272260] (WB, Mouse)
• Park NS, Park YK, Ramalingam M et al. Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3. J. Cell. Mol. Med. 2018-09-24 [PMID: 30246484] (WB, Human)

Bioinformatics

• Gene Symbol: TNFRSF10B
• Entrez:
  • 8795(Human)
• Uniprot:
  • Q9QZM4()